The objective of the present study was to assess artemether-lumefantrine effectiveness in the treatment of falciparum malaria in an unsupervised outpatient setting in Africa. The study was open label prospective study, conducted in occupational health clinic, Mozambique in semi-immune Mozambican adults. 28-day treatment failure was considered as outcome measure. 54/54 subjects were smear negative on day 2, and at 'day 28' (range 26-34 days).  It was concluded that artemether-lumefantrine is effective in semi-immune adults in an unsupervised outpatient setting in Southern Africa, with no evidence of recrudescence.

A crude acetone/water (50/50) extract of neem leaves (IRAB) was evaluated for activity against the asexual (trophozoites/schizonts) and the sexual (gametocytes) forms of the malarial parasite, Plasmodium falciparum, in vitro. In separate 72 hour cultures of both asexual parasites and mature gametocytes treated with IRAB (0.5 mcg/mL), parasite numbers were less than 50% of the numbers in control cultures, which had 8.0% and 8.5% parasitemia, respectively. In cultures containing 2.5 mcg/mL, asexual parasites and mature and immature gametocytes were reduced to 0.1%, 0.2%, and 0% parasitemia, respectively. There were no parasites in the cultures containing 5.0 mcg/mL. This extract, if found safe, may provide materials for development of new antimalarial drugs that may be useful both in treatment of malaria as well as the control of its transmission through gametocytes.